Hsien-Yuan Lane Selected Research

D-Amino-Acid Oxidase (D-Amino Acid Dehydrogenase)

1/2022	Blood D-Amino Acid Oxidase Levels Increased With Cognitive Decline Among People With Mild Cognitive Impairment: A Two-Year Prospective Study.
1/2022	Effects of Sodium Benzoate, a D-Amino Acid Oxidase Inhibitor, on Perceived Stress and Cognitive Function Among Patients With Late-Life Depression: A Randomized, Double-Blind, Sertraline- and Placebo-Controlled Trial.
10/2021	d-Amino Acids and pLG72 in Alzheimer's Disease and Schizophrenia.
1/2021	Effect of Sodium Benzoate on Cognitive Function Among Patients With Behavioral and Psychological Symptoms of Dementia: Secondary Analysis of a Randomized Clinical Trial.
1/2021	Brain Activity of Benzoate, a D-Amino Acid Oxidase Inhibitor, in Patients With Mild Cognitive Impairment in a Randomized, Double-Blind, Placebo Controlled Clinical Trial.
1/2020	An Ensemble Approach to Predict Schizophrenia Using Protein Data in the N-methyl-D-Aspartate Receptor (NMDAR) and Tryptophan Catabolic Pathways.
1/2020	Precision Medicine of Sodium Benzoate for the Treatment of Behavioral and Psychological Symptoms of Dementia (BPSD).
1/2020	Novel Treatment for the Most Resistant Schizophrenia: Dual Activation of NMDA Receptor and Antioxidant.
1/2018	Sodium Benzoate, a D-Amino Acid Oxidase Inhibitor, Added to Clozapine for the Treatment of Schizophrenia: A Randomized, Double-Blind, Placebo-Controlled Trial.
1/2018	Combination of G72 Genetic Variation and G72 Protein Level to Detect Schizophrenia: Machine Learning Approaches.

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Hsien-Yuan Lane Research Topics

Disease

61	Schizophrenia (Dementia Praecox) 01/2022 - 08/2002
23	Alzheimer Disease (Alzheimer's Disease) 01/2022 - 02/2002
16	Cognitive Dysfunction 01/2022 - 09/2012
11	Major Depressive Disorder (Major Depressive Disorders) 01/2022 - 01/2008
8	Dementia (Dementias) 01/2021 - 02/2002
6	Neoplasms (Cancer) 01/2022 - 09/2011
6	Neurobehavioral Manifestations 02/2017 - 03/2003
4	Mental Disorders (Mental Disorder) 09/2021 - 01/2020
4	Parkinson Disease (Parkinson's Disease) 04/2020 - 09/2014
4	Breast Neoplasms (Breast Cancer) 07/2016 - 09/2011
3	Heroin Dependence (Heroin Abuse) 05/2022 - 05/2012
3	Inflammation (Inflammations) 03/2022 - 01/2013
3	Attention Deficit Disorder with Hyperactivity (Attention Deficit Hyperactivity Disorder) 10/2021 - 01/2014
3	Psychotic Disorders (Schizoaffective Disorder) 01/2019 - 01/2014
3	Alcoholism (Alcohol Abuse) 12/2014 - 01/2005
3	Body Weight (Weight, Body) 04/2006 - 03/2003
3	Weight Gain 04/2006 - 03/2003
2	Bipolar Disorder (Manic Depressive Psychosis) 01/2022 - 01/2014
2	Neurodegenerative Diseases (Neurodegenerative Disease) 10/2021 - 08/2021
2	Opioid-Related Disorders (Opiate Addiction) 01/2021 - 01/2013
2	Metabolic Syndrome (Dysmetabolic Syndrome X) 01/2021 - 10/2010
2	Hyperprolactinemia 01/2021 - 08/2016
2	Anti-N-Methyl-D-Aspartate Receptor Encephalitis 01/2020 - 01/2019
2	Treatment-Resistant Schizophrenia 01/2020 - 01/2018
2	Brain Diseases (Brain Disorder) 01/2020 - 06/2019
2	Autism Spectrum Disorder 01/2019 - 03/2016
2	Hallucinations (Hallucination) 01/2019 - 03/2005
2	Neuroleptic Malignant Syndrome 11/2016 - 01/2011
2	Carcinogenesis 07/2016 - 11/2015
2	Mania (Manias) 01/2016 - 01/2014
2	Neoplasm Metastasis (Metastasis) 08/2014 - 01/2012
2	Stroke (Strokes) 05/2014 - 01/2006
2	Glaucoma 02/2013 - 11/2011
1	Cardiac Sudden Death (Sudden Cardiac Arrest) 05/2022
1	Myocarditis (Carditis) 03/2022
1	Obesity 03/2022
1	Drug-Related Side Effects and Adverse Reactions 03/2022
1	Pneumonia (Pneumonitis) 03/2022
1	Agranulocytosis (Granulocytopenia) 03/2022

Drug/Important Bio-Agent (IBA)

36	Antipsychotic Agents (Antipsychotics)IBA 01/2020 - 02/2002
19	N-Methyl-D-Aspartate Receptors (NMDA Receptors)IBA 01/2022 - 03/2004
17	Biomarkers (Surrogate Marker)IBA 01/2022 - 09/2011
16	Risperidone (Risperdal Consta)FDA LinkGeneric 09/2014 - 02/2002
15	N-Methylaspartate (NMDA)IBA 04/2020 - 03/2004
13	D-Amino-Acid Oxidase (D-Amino Acid Dehydrogenase)IBA 01/2022 - 12/2013
11	Clozapine (Clozaril)FDA LinkGeneric 03/2022 - 06/2004
11	Sarcosine (Methylglycine)IBA 01/2020 - 03/2004
9	Pharmaceutical PreparationsIBA 03/2022 - 01/2008
9	Glutamic Acid (Glutamate)FDA Link 09/2021 - 02/2012
8	Proteins (Proteins, Gene)FDA Link 01/2022 - 12/2013
8	Sodium Benzoate FDA Link 01/2022 - 12/2013
8	Serine (L-Serine)FDA Link 10/2021 - 03/2004
8	Glycine (Aminoacetic Acid)FDA LinkGeneric 10/2016 - 03/2004
7	Benzoates (Benzoate)IBA 01/2021 - 12/2013
7	Glutamate Receptors (Glutamate Receptor)IBA 04/2020 - 03/2004
6	Olanzapine (Zyprexa)FDA Link 01/2021 - 10/2002
5	Methadone (Dolophine)FDA LinkGeneric 05/2022 - 05/2012
5	Antidepressive Agents (Antidepressants)IBA 11/2021 - 11/2011
5	Glycine Plasma Membrane Transport ProteinsIBA 01/2020 - 03/2004
5	Cycloserine (Seromycin)FDA Link 09/2012 - 03/2004
4	Messenger RNA (mRNA)IBA 01/2022 - 01/2016
4	Amino Acids FDA Link 10/2021 - 11/2017
4	Fluoxetine (Prozac)FDA LinkGeneric 11/2011 - 01/2008
3	Hormones (Hormone)IBA 08/2021 - 01/2012
3	ProlactinIBA 01/2021 - 08/2012
3	Paliperidone Palmitate FDA Link 11/2019 - 01/2011
3	Memantine (Namenda)FDA Link 01/2019 - 09/2012
3	Brain-Derived Neurotrophic Factor (BDNF)IBA 01/2017 - 04/2006
2	C-Reactive ProteinIBA 03/2022 - 01/2019
2	Valproic Acid (Depakote)FDA LinkGeneric 03/2022 - 06/2016
2	Methylphenidate (Ritalin)FDA LinkGeneric 10/2021 - 10/2016
2	Cystine (L-Cystine)IBA 09/2021 - 01/2016
2	AntiportersIBA 09/2021 - 01/2016
2	MelatoninIBA 02/2021 - 01/2020
2	Cholinergic Agents (Cholinergics)IBA 02/2021 - 07/2015
2	Dopamine Receptors (Dopamine Receptor)IBA 01/2020 - 02/2017
2	Alanine (L-Alanine)FDA Link 10/2019 - 09/2006
2	Donepezil (Aricept)FDA LinkGeneric 06/2019 - 07/2015
2	Cholinesterase Inhibitors (Anticholinesterases)IBA 01/2018 - 07/2015
2	Aripiprazole (Abilify)FDA Link 01/2018 - 09/2014
2	Serotonin (5 Hydroxytryptamine)IBA 02/2017 - 06/2009
2	EnzymesIBA 07/2016 - 11/2006
2	Ketamine FDA LinkGeneric 01/2016 - 01/2016
2	Quetiapine Fumarate (Seroquel)FDA Link 09/2014 - 01/2008
2	5-HT2A Serotonin Receptor (5 HT2A Receptor)IBA 07/2013 - 02/2010
2	Caveolin 1IBA 03/2013 - 10/2011
2	Retinaldehyde (Retinal)IBA 02/2013 - 11/2011
2	CholesterolIBA 01/2013 - 06/2004
2	Haloperidol (Haldol)FDA LinkGeneric 10/2010 - 02/2002
2	Fluvoxamine (Luvox)FDA LinkGeneric 12/2004 - 06/2004
1	Oral ContraceptivesIBA 03/2022
1	Sertraline (Zoloft)FDA LinkGeneric 01/2022
1	Aeromonas hydrophilia lipase-acyltransferase (GCAT)IBA 01/2022
1	Glutathione (Reduced Glutathione)IBA 11/2021
1	Lisdexamfetamine Dimesylate FDA Link 10/2021

Therapy/Procedure

15	Therapeutics 10/2021 - 12/2006
4	Precision Medicine 01/2022 - 01/2019
3	Duration of Therapy 01/2018 - 03/2003
2	Drug Therapy (Chemotherapy) 10/2021 - 08/2014
2	Patient Readmission 12/2010 - 01/2008